Is it possible to configure two factor authentication with CLM 6.0.1?

CLM includes smart card support. See https://jazz.net/library/article/606 and other help for details. Is this the sort of thing you're looking for?

 I am not aware of two factor authentication options.  But 6.0 did add two single sign-on options.  So, if you are in an environment that uses two factor authentication to the workstation.  It maybe possible to use that same token as a part of a single sign-on architecture and 'achieve' a two factor authentication.  For example, if I have to two factor authenticate to my workstation and my web browser can use that token, then I have ,effectively, two factor authenticated to any web apps on the the workstation.