As far as I am aware, the answer is: No.
And it might also not always work anyway and could cause more problems than it solves.

In additions as far as I am aware, the web UI prompts me if I want to close a work item editor where I have done changes (usually also if I try to close the tabs or the browser). The same applies to the Eclipse UI and other IDE's where I am usually notified that I have unsaved changes and I can ignore that and close anyway with the obvious result.

So from my perspective RTC/CLM acts in a standard way and any user should be able to learn to deal with it. Since this is typical in all applications I can't see a need to change that in RTC and, again, I think an auto save is even more dangerous than having to redo a change.