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Difference Between 'Setting up Work item approvals' and 'Modify work items approvals' permission in RTC

Hello Everyone,
Is there any Permission by which we can restrict modifying approver based upon role.I am not getting the use of 'modifying work item approval permission' as it is not having any impact on the work item,as per expectation.Kindly provide documents or reference,which describe the difference between 'setting up work item approvals' and 'Modify work items Approvals'.
Thanks and Regards,
Jyoti